Structure of PDB 5hkp Chain A Binding Site BS01
Receptor Information
>5hkp Chain A (length=313) Species:
10090
(Mus musculus) [
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VLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAG
YNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACV
NAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTP
ELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHC
AVASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLH
KHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAA
QMGNEAVQQILSE
Ligand information
>5hkp Chain C (length=12) Species:
9606
(Homo sapiens) [
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SPRGCADGRDAD
Receptor-Ligand Complex Structure
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PDB
5hkp
Crystal structure of a tankyrase 1-telomere repeat factor 1 complex.
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
R361 S363 L368 G371 Y372 L396 N401 Y405 H407 D425 W427 F429 E434 R440
Binding residue
(residue number reindexed from 1)
R40 S42 L47 G50 Y51 L75 N80 Y84 H86 D104 W106 F108 E113 R119
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:5hkp
,
PDBe:5hkp
,
PDBj:5hkp
PDBsum
5hkp
PubMed
27050267
UniProt
Q6PFX9
|TNKS1_MOUSE Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=Tnks)
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