Structure of PDB 5h7k Chain A Binding Site BS01

Receptor Information
>5h7k Chain A (length=367) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RREEMIAKIKELMLQPERIRNIGIAAHIDHGKTTLSDNLLAGAGMISEEL
ARGITINAANVSMVHNYEGKDYLINLIDTPGHVDFGGDVTRAMRAIDGVI
IVVDAVEGVMPQTETVVRQALREYVKPVLFINKVDRLIRELKLTPQQMME
RFSKIIMDVNRLIQRYAPEEYKKKWMVKVEDGSVAFGSAYYNWALSVPFM
KRTGVKFNEIIDLTLKGDNRTLRQKAPLHVVVLDMVVRHLPSPIEAQKYR
IPHLWEGDISSDIGQAMLNCDPKGKMVMVVTKIIIDKHAGEVATGRVWSG
TVKSGQEVYLINTKRKARIQQVGIYMGPERINMEAVPAGNIVAVTGLRDA
MAGETVAEEQIEPFEAL
Ligand information
Ligand IDGDP
InChIInChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H15 N5 O11 P2
NameGUANOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL384759
DrugBankDB04315
ZINCZINC000008215481
PDB chain5h7k Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5h7k The C-terminal helix of ribosomal P stalk recognizes a hydrophobic groove of elongation factor 2 in a novel fashion
Resolution1.599 Å
Binding residue
(original residue number in PDB)		D34 G36 K37 T38 T39 H101 N151 K152 D154 R155 S207 Y209
Binding residue
(residue number reindexed from 1)		D29 G31 K32 T33 T34 H82 N132 K133 D135 R136 S188 Y190
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:5h7k, PDBe:5h7k, PDBj:5h7k
PDBsum5h7k
PubMed29471537
UniProtO59521|EF2_PYRHO Elongation factor 2 (Gene Name=fusA)

[Back to BioLiP]