Structure of PDB 5h2v Chain A Binding Site BS01

Receptor Information
>5h2v Chain A (length=1027) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALPEEVNRTLLQIVQAFASNQIRSVAEKALSEEWITENNIEYLLTFLAEQ
AAFSQDTTVAALSAVLFRKLALKAPITHIRKEVLAQIRSSLLKGFLSERA
DSIRHKLSDAIAECVQDDLPAWPELLQALIESLKSGNPNFRESSFRILTT
VPYLITAVDINSILPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSK
LGILLPSLLNSLPRFLDDGKDDALASVFESLIELVELAPKLFKDMFDQII
QFTDMVIKNKDLEPPARTTALELLTVFSENAPQMCKSNQNYGQTLVMVTL
IMMTEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLA
APLFQYLQQMITSTEWRERFAAMMALSSAAEGCADVLIGEIPKILDMVIP
LINDPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECTS
RVQTHAAAALVNFSEFASKDILEPYLDSLLTNLLVLLQSNKLYVQEQALT
TIAFIAEAAKNKFIKYYDTLMPLLLNVLKVNSVLKGKCMECATLIGFAVG
KEKFHEHSQELISILVALQNSDALRSYLEQSWSRICRILGDDFVPLLPIV
IPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVKHIAIHTSVLDDKVSA
MELLQSYATLLRGQFAVYVKEVMEEIALPSLDFYLHDGVRAAGATLIPIL
LSCLLAANEELVLLWHKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMG
DNCLSEDQLAAFTKGVSANLTDTYERMQDDEYNEDFTDEDLLDEINKSIA
AVLKTTNGHYLKNLENIWPMINTFLLDNEPILVIFALVVIGDLIQYGGEQ
TASMKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYADVCIPTL
DTLVQIVDGSKLEENRSSTENASAAIAKILYAYDTYTANWFKTLPTITDK
EAASFNYQFLSQLIEPIVCAQSNISAVVDSVIQALNERSLEGQTVISSVK
KLLGFLDAMAIFNRYPADIMEKVHKWF
Ligand information
>5h2v Chain B (length=5) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GIYKK
Receptor-Ligand Complex Structure
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PDB5h2v Structures of the Karyopherins Kap121p and Kap60p Bound to the Nuclear Pore-Targeting Domain of the SUMO Protease Ulp1p
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Q350 D353 E396 N430 H470 A473 A474 N477
Binding residue
(residue number reindexed from 1)		Q335 D338 E381 N415 H455 A458 A459 N462
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008139 nuclear localization sequence binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006406 mRNA export from nucleus
GO:0006606 protein import into nucleus
GO:0007088 regulation of mitotic nuclear division
GO:0015031 protein transport
GO:0060188 regulation of protein desumoylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5h2v, PDBe:5h2v, PDBj:5h2v
PDBsum5h2v
PubMed27939291
UniProtP32337|IMB3_YEAST Importin subunit beta-3 (Gene Name=PSE1)

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