Structure of PDB 5h1k Chain A Binding Site BS01

Receptor Information

>5h1k Chain A (length=674) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QEPRTLPPSPNWYCARCSDAVPGGLFGFAARTSVFLVRVGPGAGESPGTP
PFRVIGELVGHTERVSGFTFSHHPGQYNLCATSSDDGTVKIWDVETKTVV
TEHALHQHTISTLHWSPRVKDLIVSGDEKGVVFCYWFNRNDSQHLFIEPR
TIFCLTCSPHHEDLVAIGYKDGIVVIIDISKKGEVIHRLRGHDDEIHSIA
WCPLPGEDCLSIGCYLATGSKDQTIRIWSCSRGRGVMILKLPFKERLWLT
LHWPSNQPTQLVSSCFGGELLQWDLTQKYTLFSASSEGQNHSRIVFNLCP
LQTEDDKQLLLSTSMDRDVKCWDIATLECSWTLPSLGGFAYSLAFSSVDI
GSLAIGVGDGMIRVWNTLSIKNNYDVKNFWQGVKSKVTALCWHPTKEGCL
AFGTDDGKVGLYDTYSNKPPQISSTYHKKTVYTLAWGPPVPPMSLPSLAL
YSCGGEGIVLQHNPWKLSGEAFDINKLIRDTNSIKYKLPVHTEISWKADG
KIMALGNEDGSIEIFQIPNLKLICTIQQHHKLVNTISWHHEHGSQPELSY
LMASGSNNAVIYVHNLKTVIESSPESPVTITEPYRTLSGHTAKITSVAWS
PHHDGRLVSASYDGTAQVWDALREEPLCNFRGHRGRLLCVAWSPLDPDCI
YSGADDFCVHKWLTSMQDHSRPPQ

Ligand information

>5h1k Chain C (length=13) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gcaauuuuugaca

.............

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5h1k Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5
Resolution	1.9 Å
Binding residue (original residue number in PDB)	N13 W14 Y15 R33 R66 R284 R335 G380 F381 Y383 W422 K428 E556 K579 L580 N605 Y660
Binding residue (residue number reindexed from 1)	N11 W12 Y13 R31 R64 R246 R293 G338 F339 Y341 W380 K386 E508 K531 L532 N557 Y612
Binding affinity	PDBbind-CN: Kd=0.24uM

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:5h1k, PDBe:5h1k, PDBj:5h1k
PDBsum	5h1k
PubMed	27881601
UniProt	Q8TEQ6\|GEMI5_HUMAN Gem-associated protein 5 (Gene Name=GEMIN5)

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