Structure of PDB 5h19 Chain A Binding Site BS01

Receptor Information
>5h19 Chain A (length=355) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECH
SQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINP
ITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVA
IFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKES
YDYNPPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWK
PGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQ
VGKLYVWDLEVEKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIW
RWDRL
Ligand information
>5h19 Chain B (length=29) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SMFSSNRQKILERTEILNQEWKQRRIQPV
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5h19 Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
Resolution1.9 Å
Binding residue
(original residue number in PDB)		W103 H104 S105 K106 D109 W152 Y154 S159 H160 P161 P177 I178 R201 L246 L247 L315 G316 D317 L318 F372 W373 Q374 V393 E394 R420
Binding residue
(residue number reindexed from 1)		W26 H27 S28 K29 D32 W75 Y77 S82 H83 P84 P100 I101 R124 L169 L170 L233 G234 D235 L236 F290 W291 Q292 V311 E312 R335
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:5h19, PDBe:5h19, PDBj:5h19
PDBsum5h19
PubMed28072869
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

[Back to BioLiP]