Structure of PDB 5h15 Chain A Binding Site BS01

Receptor Information
>5h15 Chain A (length=356) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECH
SQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINP
ITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVA
IFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKES
YDYPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPG
KMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVG
KLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASI
WRWDRL
Ligand information
>5h15 Chain C (length=29) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SMFSSNRQKILERTEILNQEWKQRRIQPV
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5h15 Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
Resolution2.27 Å
Binding residue
(original residue number in PDB)		W103 H104 S105 E107 D109 V112 Y154 S159 H160 P161 P177 I178 R201 L246 L315 G316 D317 L318 M336 L353 F372 W373 Q374 L391 E392 E394 R420
Binding residue
(residue number reindexed from 1)		W26 H27 S28 E30 D32 V35 Y77 S82 H83 P84 P100 I101 R124 L169 L231 G232 D233 L234 M252 L269 F288 W289 Q290 L307 E308 E310 R336
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:5h15, PDBe:5h15, PDBj:5h15
PDBsum5h15
PubMed28072869
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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