Structure of PDB 5gxh Chain A Binding Site BS01

Receptor Information

>5gxh Chain A (length=672) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QEPRTLPPSPNWYCARCSDAVPGGLFGFAARTSVFLVRVGPGAGESPGTP
PFRVIGELVGHTERVSGFTFSHHPGQYNLCATSSDDGTVKIWDVETKTVV
TEHALHQHTISTLHWSPRVKDLIVSGDEKGVVFCYWFNRNDSQHLFIEPR
TIFCLTCSPHHEDLVAIGYKDGIVVIIDISKKGEVIHRLRGHDDEIHSIA
WCPLPGEGCYLATGSKDQTIRIWSCSRGRGVMILKLPFLKRRERLWLTLH
WPSNQPTQLVSSCFGGELLQWDLTQRRKYTLFSASSEGQNHSRIVFNLCP
LQTEDDKQLLLSTSMDRDVKCWDIATLECSWTLPSLGGFAYSLAFSSVDI
GSLAIGVGDGMIRVWNTLSIKNNYDVKNFWQGVKSKVTALCWHPTKEGCL
AFGTDDGKVGLYDTYSNKPPQISSTYHKKTVYTLAWGPPVPPMSSLALYS
CGGEGIVLQHNPWKLSGEAFDINKLIRDTNSIKYKLPVHTEISWKADGKI
MALGNEDGSIEIFQIPNLKLICTIQQHHKLVNTISWHHEHGSQPELSYLM
ASGSNNAVIYVHNLKTVIESSPESPVTITEPYRTLSGHTAKITSVAWSPH
HDGRLVSASYDGTAQVWDALREEPLCNFRGHQGRLLCVAWSPLDPDCIYS
GADDFCVHKWLTSMQDHSRPPQ

Ligand information

>5gxh Chain B (length=7) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

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Receptor-Ligand Complex Structure

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Structure summary

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PDB	5gxh Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly
Resolution	1.8 Å
Binding residue (original residue number in PDB)	N13 W14 Y15 R33 R66 R359 G380 F381 Y383 Y474 T540 N582 K641 Y660 R684
Binding residue (residue number reindexed from 1)	N11 W12 Y13 R31 R64 R317 G338 F339 Y341 Y432 T490 N532 K591 Y610 R634
Binding affinity	PDBbind-CN: Kd=2.4uM

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:5gxh, PDBe:5gxh, PDBj:5gxh
PDBsum	5gxh
PubMed	27881600
UniProt	Q8TEQ6\|GEMI5_HUMAN Gem-associated protein 5 (Gene Name=GEMIN5)

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