Structure of PDB 5gwy Chain A Binding Site BS01

Receptor Information
>5gwy Chain A (length=298) Species: 277944 (Human coronavirus NL63) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKKMAQPSGCVERCVVRVCYGSTVLNGVWLGDTVTCPRHVIAPSTTVLID
YDHAYSTMRLHNFSVSHNGVFLGVVGVTMHGSVLRIKVSQSNVHTPKHVF
KTLKPGDSFNILACYEGIASGVFGVNLRTNFTIKGSFINGACGSPGYNVR
NDGTVEFCYLHQIELGSGAHVGSDFTGSVYGNFDDQPSLQVESANLMLSD
NVVAFLYAALLNGCRWWLCSTRVNVDGFNEWAMANGYTSVSSVECYSILA
AKTGVSVEQLLASIQHLHEGFGGKNILGYSSLCDEFTLAEVVKQMYGV
Ligand information
Receptor-Ligand Complex Structure
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PDB5gwy Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design.
Resolution2.852 Å
Binding residue
(original residue number in PDB)		H41 F139 C144 H163 Q164 I165 E166 D187 P189 S190 L191
Binding residue
(residue number reindexed from 1)		H39 F137 C142 H161 Q162 I163 E164 D185 P187 S188 L189
Enzymatic activity
Catalytic site (original residue number in PDB) H41 G142 C144
Catalytic site (residue number reindexed from 1) H39 G140 C142
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:5gwy, PDBe:5gwy, PDBj:5gwy
PDBsum5gwy
PubMed26948040
UniProtP0C6U6|R1A_CVHNL Replicase polyprotein 1a (Gene Name=1a)

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