Structure of PDB 5guh Chain A Binding Site BS01

Receptor Information
>5guh Chain A (length=759) Species: 7091 (Bombyx mori) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ISILRTRPEAVTSKKGTSGTPLDLLANYFTVETTPKWGLYQYHVDISPEE
DSTGVRKALMRVHSKTLGGYLFDGTVLYTVNRLHPDPMELYSDRKTDNER
MRILIKLTCEVSPGDYHYIQIFNIIIRKCFNLLKLQLMGRDYFDPEAKID
IPEFKLQIWPGYKTTINQYEDRLLLVTEIAHKVLRMDTVLQMLSEYAATK
KIFLEDVVGKIVMTDYNKRTYRVDDVANVSPKSTFKMRDENITYIEYYYK
KYNLRIQDPGQPLLISRSKPREIRAGLPELIYLVPELCRQTGLSDEMRAN
FKLMRSLDVHTKIGPDKRIEKLNNFNRRFTSTPEVVEELATWSLKLSKEL
VKIKGRQLPPENIIQANNVKYPAGDTTEGWTRDMRSKHLLAIAQLNSWVV
ITPERQRRDTESFIDLIIKTGGGVGFRMRSPDLVVIRHDGPIEYANMCEE
VIARKNPALILCVLARNYADRYEAIKKKCTVDRAVPTQVVCARNMSSKSA
MSIATKVAIQINCKLGGSPWTVDIPLPSLMVVGYDVCHDTRSKEKSFGAF
VATLDKQMTQYYSIVNAHLSSHMGFNIASAVKKFREKNGTYPARIFIYRD
GVGDGQIPYVHSHEVAEIKKKLAEIYAGVEIKLAFIIVSKRINTRIFVQR
GRSGENPRPGTVIDDVVTLPERYDFYLVSQNVREGTIAPTSYNVIEDTTG
LNPDRIQRLTYKLTHLYFNCSSQVRVPSVCQYAHKLAFLAANSLHNQPHY
SLNETLYFL
Ligand information
Receptor-Ligand Complex Structure
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PDB5guh Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA
Resolution2.4 Å
Binding residue
(original residue number in PDB)		Y350 Y355 F370 Y379 Y382 Y383 K386 Y387 E414 I416 Y417 N602 Y607 K611 Q623 V624 C626 N629 K641 V642 Q645 K649 Y857 N859 C860 Q871 L899
Binding residue
(residue number reindexed from 1)		Y216 Y221 F235 Y244 Y247 Y248 K251 Y252 E279 I281 Y282 N467 Y472 K476 Q488 V489 C491 N494 K506 V507 Q510 K514 Y717 N719 C720 Q731 L759
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0034584 piRNA binding
GO:0046872 metal ion binding
GO:0061980 regulatory RNA binding
Biological Process
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0030237 female sex determination
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0034587 piRNA processing
GO:0051321 meiotic cell cycle
GO:0140965 secondary piRNA processing
GO:0140991 piRNA-mediated gene silencing by mRNA destabilization
Cellular Component
GO:0005737 cytoplasm
GO:0043186 P granule
GO:1990923 PET complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5guh, PDBe:5guh, PDBj:5guh
PDBsum5guh
PubMed27693359
UniProtA8D8P8|SIWI_BOMMO Piwi-like protein Siwi (Gene Name=Siwi)

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