Structure of PDB 5gsa Chain A Binding Site BS01

Receptor Information
>5gsa Chain A (length=359) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECH
SQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINP
ITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVA
IFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKES
YDYNPRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCW
KPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGN
QVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDD
ASIWRWDRL
Ligand information
>5gsa Chain C (length=29) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SMFSSNRQKILERTEILNQEWKQRRIQPV
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5gsa An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of
Resolution2.49 Å
Binding residue
(original residue number in PDB)		W103 H104 S105 E107 D109 V112 Y154 S159 H160 P161 P177 I178 R201 L246 L247 L315 G316 D317 L318 F372 W373 Q374 L391 E392 E394 R420
Binding residue
(residue number reindexed from 1)		W26 H27 S28 E30 D32 V35 Y77 S82 H83 P84 P100 I101 R124 L169 L170 L234 G235 D236 L237 F291 W292 Q293 L310 E311 E313 R339
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:5gsa, PDBe:5gsa, PDBj:5gsa
PDBsum5gsa
PubMed28135235
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

[Back to BioLiP]