Structure of PDB 5gp7 Chain A Binding Site BS01
Receptor Information
>5gp7 Chain A (length=163) Species:
9606
(Homo sapiens) [
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GPGSDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLA
AGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNT
CVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT
ADDIRALLIDAMP
Ligand information
>5gp7 Chain B (length=10) Species:
9606
(Homo sapiens) [
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SLSRTPADGR
Receptor-Ligand Complex Structure
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PDB
5gp7
USP25 regulates Wnt signaling by controlling the stability of tankyrases
Resolution
1.502 Å
Binding residue
(original residue number in PDB)
R836 S838 L843 G846 Y847 L871 N876 Y880 H882 D900 W902 F904 E909
Binding residue
(residue number reindexed from 1)
R42 S44 L49 G52 Y53 L77 N82 Y86 H88 D106 W108 F110 E115
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:5gp7
,
PDBe:5gp7
,
PDBj:5gp7
PDBsum
5gp7
PubMed
28619731
UniProt
O95271
|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)
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