Structure of PDB 5gmg Chain A Binding Site BS01

Receptor Information
>5gmg Chain A (length=762) Species: 9544 (Macaca mulatta) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RWFPKTLPCDVTLDHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDIS
PASFHRLVHLVEIDFRCNCVPIRLGSKSNMCPRRLQIKPRSFSGLTYLKS
LYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEQLTELANIEILYLGQ
NCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVLPSTLTELY
LYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPCKNNSPLQI
PVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQNFLAKEIG
DAKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYV
FKELKSFQLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVN
KISPLYYFRYDKYARSCRSCYKYGQTLDLSKNSIFFIKSSDFQHLSFLKC
LNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELRKLEVL
DISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESL
RTLEFRGNHLDVLWRDGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFD
GMPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLSHNQLTTVPERLSNC
SRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENV
LNNLKMLLLHHNRFLCTCDAVWFVWWVQHTEVTIPYLATDVTCVGPGAHK
GQSVISLDLYTC
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5gmg Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Resolution2.6 Å
Binding residue
(original residue number in PDB)		I74 H76 C98 L105 S107 D135 E156 Q181 Y184 R186 R467 Y468 A472 R473 S474 C475
Binding residue
(residue number reindexed from 1)		I43 H45 C67 L74 S76 D104 E125 Q150 Y153 R155 R409 Y410 A414 R415 S416 C417
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5gmg, PDBe:5gmg, PDBj:5gmg
PDBsum5gmg
PubMed27742543
UniProtB3Y653

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