Structure of PDB 5gmf Chain A Binding Site BS01

Receptor Information
>5gmf Chain A (length=776) Species: 9544 (Macaca mulatta) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPWARWFPKTLPCDVTLDVSKNHVIVDCTDKHLTEIPGGIPTNTTNLTLT
INHIPDISPASFHRLVHLVEIDFRCNCVPIRLGSKSNMCPRRLQIKPRSF
SGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKEQLTELAN
IEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTTVPTVL
PSTLTELYLYNNMIAEIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCTPC
KNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINNLQELDLSQ
NFLAKEIGDAKFLHFLPNLIQLDLSFNFELQVYRASMNLSQAFSSLKSLK
ILRIRGYVFKELKSFQLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRL
KVIDLSVNKISPVLEQLYYFRYDKYARSCRFKSCYKYGQTLDLSKNSIFF
IKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLL
HSTAFEELRKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDND
ISSSTSRTMESESLRTLEFRGNHLDVLWRDGDNRYLQLFKNLLKLEELDI
SKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFIWEKLRYLKNLETLDLS
HNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSN
KIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVQHTEVTIPY
LATDVTCVGPGAHKGQSVISLDLYTC
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5gmf Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Resolution2.5 Å
Binding residue
(original residue number in PDB)		I74 H76 C98 L105 D135 E156 Q181 Y184 R186 R467 Y468 A472 R473 S474 C475
Binding residue
(residue number reindexed from 1)		I51 H53 C75 L82 D112 E133 Q158 Y161 R163 R421 Y422 A426 R427 S428 C429
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5gmf, PDBe:5gmf, PDBj:5gmf
PDBsum5gmf
PubMed27742543
UniProtB3Y653

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