Structure of PDB 5gj9 Chain A Binding Site BS01

Receptor Information
>5gj9 Chain A (length=298) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KFPVVDLSKLNGEERDQTMALINEACENWGFFEIVNHGLPHDLMDKIEKM
TKDHYKTCQEQKFNDMLKSKGLDNLETEVEDVDWESTFYVRHLPQSNLND
ISDVSDEYRTAMKDFGKRLENLAEDLLDLLCENLGLEKGYLKKVFHGTKG
PTFGTKVSNYPPCPKPEMIKGLRAHTDAGGIILLFQDDKVSGLQLLKDGD
WIDVPPLNHSIVINLGDQLEVITNGKYKSVLHRVVTQQEGNRMSVASFYN
PGSDAEISPATSLVEKDSEYPSFVFDDYMKLYAGVKFQPKEPRFAAMK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5gj9 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5gj9 Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		H180 D182 H237
Binding residue
(residue number reindexed from 1)		H175 D177 H232
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K161 H180 D182 H237
Catalytic site (residue number reindexed from 1) K156 H175 D177 H232
Enzyme Commision number 1.14.17.4: aminocyclopropanecarboxylate oxidase.
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0009815 1-aminocyclopropane-1-carboxylate oxidase activity
GO:0016491 oxidoreductase activity
GO:0031418 L-ascorbic acid binding
GO:0046872 metal ion binding
Biological Process
GO:0006952 defense response
GO:0009693 ethylene biosynthetic process
GO:0009727 detection of ethylene stimulus
GO:0010030 positive regulation of seed germination
GO:0071398 cellular response to fatty acid
GO:0071732 cellular response to nitric oxide
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009505 plant-type cell wall
GO:0009506 plasmodesma

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5gj9, PDBe:5gj9, PDBj:5gj9
PDBsum5gj9
PubMed28604689
UniProtQ41931|ACCO2_ARATH 1-aminocyclopropane-1-carboxylate oxidase 2 (Gene Name=ACO2)

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