Structure of PDB 5g5t Chain A Binding Site BS01

Receptor Information
>5g5t Chain A (length=670) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVLNKVTYKINAYKIKEEFIPKEVHFYRIKSRFVNFYGGMIINKKDKSFV
LPYKVDNKVLKPIDIEYIKSLKLEYVKPEIAEKLVRGYLKSVHKIEPELS
RIIKNIRKHKVVENIKVESYCEYEVKKHDGDYYLILNFRHTASITKHLWD
FVNRDKALLEEYVGKKIIFKPNPKVRYTISLVDAPNPQKIEEIMSHIIKY
YKWSEDMVKSTFGEIDYNQPIMYCEEILEPFAPQFCNLVFYMDELDSYIL
KELQSYWRLSNENKGKIINEIAKKLRFIDNTPKELEFMKFNNTPLLVKDV
NKNPTKIYSTNTLFTWIKIYLPYDVPEIIRNKNLLTYILIDEEIKDELKA
IKDKVNKMFRNYNKIANKTELPKFNYANRWKYFSTDDIRGIIKEIKSEFN
DEICFALIIGKEYEILKKQLFDLKIISQNILWENWRKDDKGYMTNNLLIQ
IMGKLGIKYFILDSKTPYDYIMGLDTGNHRVGGCTVVYDSEGKIRRIQPI
ETPERLHLPYVIEYLENKANIDMENKNILFLRDGFIQNSERNDLKEISKE
LNSNIEVISIRKNNKYKVFTSDYRIGSVFGNDGIFLPHKTPFGSNPVKLS
TWLRFNCGNEEGLKINESIMQLLYDLTKMNYSAYLRIPAPIHYADKFVKA
LGKNWKIDEELLKHGFLYFI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5g5t Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		F45 H157 F186 N189 K191 Y194 E209 I210 H213 Y217 Y218 E243 E246 P247 F248 Q457 N458 I459 L460 Q479 H625 G630 S631 N632 S669 A670 L678 R679
Binding residue
(residue number reindexed from 1)		F36 H140 F169 N172 K174 Y177 E192 I193 H196 Y200 Y201 E226 E229 P230 F231 Q428 N429 I430 L431 Q450 H588 G593 S594 N595 S632 A633 L635 R636
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0044355 clearance of foreign intracellular DNA
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:5g5t, PDBe:5g5t, PDBj:5g5t
PDBsum5g5t
PubMed28319084
UniProtQ58717|AGO_METJA Protein argonaute (Gene Name=ago)

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