Structure of PDB 5g5s Chain A Binding Site BS01

Receptor Information
>5g5s Chain A (length=692) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FTMVLNKVTYKINAYKIKEEFIPKEVHFYRIKSFVNEAFNFYRFVNFYGG
MIINKKDKSFVLPYKVDNIPIDIEYIKSLKLEYVKPEIAEKLVRGYLKSV
HKIEPELSRIIKENIKVESYCEYEVKKHDGDYYLILNFRHTASITKHLWD
FVNRDKALLEEYVGKKIIFKPNPKVRYTISLVDAPNPQKIEEIMSHIIKY
YKWSEDMVKSTFGEIDYNQPIMYCEEILEPFAPQFCNLVFYMDELDSYIL
KELQSYWRLSNENKGKIINEIAKKLRFIDNTPKELEFMKFNNTPLLVKDV
NKNPTKIYSTNTLFTWIYNQNAKIYLPYDVPEIIRNKNLLTYILIDEEIK
DELKAIKDKVNKMFRNYNKIANKTELPKFNYANRWKYFSTDDIRGIIKEI
KSEFNDEICFALIIGKEKYKDNDYYEILKKQLFDLKIISQNILWENWRKD
DKGYMTNNLLIQIMGKLGIKYFILDSKTPYDYIMGLDTGLNHRVGGCTVV
YDSEGKIRRIQPIETPAPGERLHLPYVIEYLENKANIDMENKNILFLRDG
FIQNSERNDLKEISKELNSNIEVISIRKNNKYKVFTSDYRIGSVFGNDGI
FLPHKTPFGSNPVKLSTWLRFNCGNEEGLKINESIMQLLYDLTKMNYSAL
YGEGRYLRIPAPIHYADKFVKALGKNWKIDEELLKHGFLYFI
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5g5s Chain A Residue 1714 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5g5s Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein.
Resolution2.29 Å
Binding residue
(original residue number in PDB)		A289 L292 I295 N297
Binding residue
(residue number reindexed from 1)		A272 L275 I278 N280
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0044355 clearance of foreign intracellular DNA
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5g5s, PDBe:5g5s, PDBj:5g5s
PDBsum5g5s
PubMed28319084
UniProtQ58717|AGO_METJA Protein argonaute (Gene Name=ago)

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