Structure of PDB 5g4c Chain A Binding Site BS01

Receptor Information
>5g4c Chain A (length=289) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPTGLY
DNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRL
LKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEY
PLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKV
DLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQGGMDFDSKKAYR
DVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5g4c SIRT2 Reverses 4-Oxononanoyl Lysine Modification on Histones.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		F96 F119 H187 I232 V233 F235 E237 L239 V266 Q267
Binding residue
(residue number reindexed from 1)		F43 F65 H133 I178 V179 F181 E183 L185 V212 Q213
Enzymatic activity
Catalytic site (original residue number in PDB) P94 D95 F96 R97 N168 D170 H187
Catalytic site (residue number reindexed from 1) P41 D42 F43 R44 N114 D116 H133
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:5g4c, PDBe:5g4c, PDBj:5g4c
PDBsum5g4c
PubMed27610633
UniProtQ8IXJ6|SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (Gene Name=SIRT2)

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