Structure of PDB 5g04 Chain A Binding Site BS01

Receptor Information
>5g04 Chain A (length=1437) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIAARDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVKE
SWQLRKGVSEIGEDVDYDEELYVAGNMVIWSKGSKSQALAVYKAFTVDSP
VQQALWCDFIISEVEKCICILQSSCINMHSIEGKDYIASLPFQVANVWPT
KYGLLFERSPLPTMFSMLHPLDEITPLVCKVQYVVDHAMKIVFLNTDPSI
VMTYDAVQNVHSVWTLRRVKSEEENVPIVPELCIDHLWTESQASKVFITS
DLCGQKFLCFLVESQLQLRCVKFQESTQLIFGSVTNIPAKDAAPVEKIDT
MLVLEGSGNLVLYTGVVRVGKVFIPGTYIHSIRDPVHNRVTLELSNGSMV
RITIPEIATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHS
EWNLFVTCLMNMMGYNTDSTLLFTHIPAIFFVLHLVYEELKLNTLMGEGI
CSLVELLVQLARDLKLGPYVDHYYRDYPTLVFTSEPPSIYQWVSSCLKGE
GMPPYPYLPGICERSRLVVLSIALYILSSLAERLVVWMTNVGFTLRDLET
LPFGIALPIRDAIYHCREQPASDWPEAVCLLIGRQDLSKQDDGMNDMNHE
VMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHEFIEEKENRLLQ
LCQRTMALPVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNS
GNIDVPPNMTSWASFHNGVAAGLKIAPASQIDSAWIVYNKPKHAELANEY
AGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSAAKLGTMDM
SITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIGLVYQGTAHRHTAEV
LLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLNVP
EQLYQYMVGGHSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNNRSIAD
WLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIR
ENLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYL
SAPNASVTGPHNLETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGE
MNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDN
RYHLQALRHLYVLAAEPRLLVPVDVDTNTPCYALLEVTYKGTQWYEQTKE
ELMAPTLLPELHLLKQIKVKGPRYWELLIDLTQHLKSILSKDGVLYVKLR
AGQLSYKEDNSEARAFKSAFTSDPALLSFAEYFCKPTVNMGQKQEILDLF
SSVLYECVTQETPEMLPAYIAMDQAIRRLGRREMSETSELWQIKLVLEFF
SSRSHQFMNSEFLPVVKCTIDNTLDQWLQVGGDMCVHAYLSLEESQLSML
ACFLVYHSVPAPTSFAELLFKFKQLKMPVRALLRLAP
Ligand information
>5g04 Chain W (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MLRRKPTRLELKLDDIEEFENIRKD
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5g04 Molecular Mechanism of Apc/C Activation by Mitotic Phosphorylation.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		S1317 N1320
Binding residue
(residue number reindexed from 1)		S895 N898
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0060090 molecular adaptor activity
Biological Process
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0016567 protein ubiquitination
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0051301 cell division
GO:0051445 regulation of meiotic cell cycle
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0141198 protein branched polyubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5g04, PDBe:5g04, PDBj:5g04
PDBsum5g04
PubMed27120157
UniProtQ9H1A4|APC1_HUMAN Anaphase-promoting complex subunit 1 (Gene Name=ANAPC1)

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