Structure of PDB 5fw5 Chain A Binding Site BS01

Receptor Information
>5fw5 Chain A (length=139) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNG
KPADAVYGQKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLS
NNNQALRRFMQTFVLAPEGSVANKFYVHNDIFRYQDEVF
Ligand information
>5fw5 Chain C (length=23) Species: 11033 (Semliki Forest virus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
LTFGDFDEHEVDALASGITFGDF
Receptor-Ligand Complex Structure
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PDB5fw5 Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication.
Resolution1.92 Å
Binding residue
(original residue number in PDB)		F15 R17 Q18 T21 L22 Q25 R32 F33 E117 K123 F124
Binding residue
(residue number reindexed from 1)		F16 R18 Q19 T22 L23 Q26 R33 F34 E118 K124 F125
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
External links
PDB RCSB:5fw5, PDBe:5fw5, PDBj:5fw5
PDBsum5fw5
PubMed27383630
UniProtQ13283|G3BP1_HUMAN Ras GTPase-activating protein-binding protein 1 (Gene Name=G3BP1)

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