Structure of PDB 5fve Chain A Binding Site BS01

Receptor Information
>5fve Chain A (length=367) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKISVSKNDLENALRYLQAFLDKKDASSIASHIHLEVIKEKLFLKASDSD
IGLKSYIFTQSSDKEGVGTINGKKFLDIISCLKDSNIILETKDDSLAIKQ
NKSSFKLPMFDADEFPEFPVIDPKVSIEVNAPFLVDAFKKIAPVIEQTSH
KRELAGILMQFDQKHQTLSVVGTDTKRLSYTQLEKISIHSTEEDISCILP
KRALLEILKLFYENFSFKSDGMLAVIENEMHTFFTKLIDGNYPDYQKILP
KEYISSFTLGKEEFKESIKLCSSLSSTIKLTLEKNNALFESLDSEHSETA
KTSVEIEKGLDIEKAFHLGVNAKFFLEALNALGTTQFVLRCNEPSSPFLI
QESLNAKISTLMMPITL
Ligand information
Ligand ID2HO
InChIInChI=1S/C7H5F2NO/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,(H2,10,11)
InChIKeyCMWOHNIHUBDEAG-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1cc(c(cc1C(=O)N)F)F
CACTVS 3.385NC(=O)c1ccc(F)c(F)c1
ACDLabs 12.01Fc1ccc(C(=O)N)cc1F
FormulaC7 H5 F2 N O
Name3,4-difluorobenzamide
ChEMBLCHEMBL3235578
DrugBank
ZINCZINC000000156148
PDB chain5fve Chain A Residue 1375 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5fve Screening of E. coli beta-clamp Inhibitors Revealed that Few Inhibit Helicobacter pylori More Effectively: Structural and Functional Characterization.
Resolution2.07 Å
Binding residue
(original residue number in PDB)		T175 K176 R177 I248 P347 L368 M370
Binding residue
(residue number reindexed from 1)		T175 K176 R177 I248 P347 L361 M363
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0009360 DNA polymerase III complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5fve, PDBe:5fve, PDBj:5fve
PDBsum5fve
PubMed29324718
UniProtO25242|DPO3B_HELPY Beta sliding clamp (Gene Name=dnaN)

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