Structure of PDB 5fnp Chain A Binding Site BS01

Receptor Information

>5fnp Chain A (length=219) Species: 83333 (Escherichia coli K-12)

AYRDQPLGELALSIPRASALFRKYDMDYAAGGKQTLARAAARKELDVEVI
EAELAKLAEQPIEKDWRSAPLAEIIDHIIVRYHDRHREQLPELILQATKV
ERVHADKPSVPKGLTKYLTMLHEELSSHMMKEEQILFPMIKQGMGSQAMG
PISVMESEHDEAGELLEVIKHTTNNVTPPPEACTTWKAMYNGINELIDDL
MDHISLENNVLFPRALAGE

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 5fnp Chain A Residue 1221

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5fnp Crystal Structure of the Repair of Iron Centers Protein Ytfe and its Interaction with No
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): H129 E133 H160 E208
• Binding residue (residue number reindexed from 1): H128 E132 H159 E207
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.7.2.5: nitric-oxide reductase (cytochrome c).

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0005515 protein binding
• GO:0046872 metal ion binding
• GO:0098809 nitrite reductase activity

Biological Process

• GO:0006979 response to oxidative stress
• GO:0030091 protein repair
• GO:0051409 response to nitrosative stress

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:5fnp, PDBe:5fnp, PDBj:5fnp
• PDBsum: 5fnp
• PubMed: 27246459
• UniProt: P69506|YTFE_ECOLI Iron-sulfur cluster repair protein YtfE (Gene Name=ytfE)