Structure of PDB 5fmz Chain A Binding Site BS01

Receptor Information
>5fmz Chain A (length=712) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVIS
DMNFLDEEGKAYNLRPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKYLAD
LFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLSNE
SSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDVEKGIDFKLGQTIS
RLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKLTW
EDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLAKEC
LEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNELQKT
NYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTEMNL
LSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMKYV
LFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHLRG
DTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLYCRV
NGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKGDRV
NSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAESR
RLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNEWLGF
EKEGSKVLESVD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5fmz Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		K330 W364 T366 G367 D368 G369 L370 T371 Y372 P394 H506 R508 V513 T515 R558 V559 N560 G561 Q566 N692
Binding residue
(residue number reindexed from 1)		K321 W355 T357 G358 D359 G360 L361 T362 Y363 P385 H497 R499 V504 T506 R549 V550 N551 G552 Q557 N683
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5fmz, PDBe:5fmz, PDBj:5fmz
PDBsum5fmz
PubMed26711008
UniProtQ5V8Z9

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