Structure of PDB 5fby Chain A Binding Site BS01

Receptor Information
>5fby Chain A (length=490) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LAASAPRRSSLGFTLDLHRIQRDYIDLVPKHWHVISLSLSDGGHDLCITR
LQAGQAPFVLRLPLERAVFDFHTGRAELLEIIKEINRTCHDSRDMAAKGE
REKWWAEREALDQRLKELLMNIEHVWLGGFRGVFSQHGRRPELLEKFRAM
FEGVLDKHLPSRKVVLDGNVLELFIGLGDATKSGADFDEELTDLLYFVVD
ILQFHGERNAYDEIDFDSMVVETMDALMAYHAEANAAPSHAHTILVLDKQ
LHVFPWESLPCLQGLAVSRIPSLACLRKLLLDRRRSSSDPRSAGHHAPLS
GGTYILNPSSDLLSTQKTFESLFSTHLHSPNSWTRIISRPPTEPEFLSAL
THSPILLYFGHGSGAQYIRSRNIRHLDHCRATVLLMGCSSAALTAKGEFE
PSGPVWNYMLAGAPAVVGTLWDVTDRDIDRFAGGVLEGWGVLPEGCMGGR
NGLSLVQAVAKARDRCRFRYVTAAAAVVYGIPVYVDVDGK
Ligand information
Receptor-Ligand Complex Structure
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PDB5fby Structural basis of cohesin cleavage by separase.
Resolution1.898 Å
Binding residue
(original residue number in PDB)		F1695 D1698 I1702 S1718 L1959 D1960 L1985 W2128
Binding residue
(residue number reindexed from 1)		F13 D16 I20 S36 L247 D248 L273 W406
Enzymatic activity
Enzyme Commision number 3.4.22.49: separase.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5fby, PDBe:5fby, PDBj:5fby
PDBsum5fby
PubMed27027290
UniProtG0SHM3

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