Structure of PDB 5fae Chain A Binding Site BS01

Receptor Information
>5fae Chain A (length=108) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHHVVPNVVQRLFQVKGRRVVRATEVPVSWESFKNGDCFILDLGNNIHQ
WCGSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGP
KPALPAGT
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5fae Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5fae Molecular basis of a novel renal amyloidosis due to N184K gelsolin variant.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		G186 D187 E209
Binding residue
(residue number reindexed from 1)		G37 D38 E60
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0051015 actin filament binding

View graph for
Molecular Function
External links
PDB RCSB:5fae, PDBe:5fae, PDBj:5fae
PDBsum5fae
PubMed27633054
UniProtP06396|GELS_HUMAN Gelsolin (Gene Name=GSN)

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