Structure of PDB 5f9h Chain A Binding Site BS01

Receptor Information
>5f9h Chain A (length=646) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQK
GKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVEN
NDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNY
LDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIA
TVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRIC
KDLREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKY
NDALIISEHARMKDALDYLKDFFSNVRAAFDEIEQDLTQRFEEKLQELES
VSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEG
NPKLSFLKPGILTGRDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKM
IQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEA
VFREKILHIQTHEKFIRDSQPKPVPDKENKKLLCRKCKALACYTADVRVI
EECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIH
VKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPFDPAE
Ligand information
>5f9h Chain B (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aauauaauagugauauuauauuc
<<<<<<<<<....>>>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5f9h Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		I300 G326 T347 Q349 K379 Q380 H381 Q507 K508 E510 Q511 R546 K635 T636 R637 G663 T697 S698 V718 N720 S854 K888
Binding residue
(residue number reindexed from 1)		I60 G86 T107 Q109 K139 Q140 H141 Q259 K260 E262 Q263 R298 K386 T387 R388 G414 T423 S424 V444 N446 S578 K612
Binding affinityPDBbind-CN: Kd=1.8nM
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5f9h, PDBe:5f9h, PDBj:5f9h
PDBsum5f9h
PubMed26733676
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

[Back to BioLiP]