Structure of PDB 5f9f Chain A Binding Site BS01

Receptor Information
>5f9f Chain A (length=673) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQ
KGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVE
NNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFN
YLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVI
ATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRI
CKDLREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRK
YNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQEL
ESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWI
EGNPKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIAT
SVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGV
IEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQPKP
VPDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPK
PKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIAT
GVQTLYSKWKDFHFEKIPFDPAE
Ligand information
>5f9f Chain B (length=24) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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<<<<<<<<<<....>>>>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5f9f Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Resolution2.601 Å
Binding residue
(original residue number in PDB)		N298 Q299 I300 S325 G326 T347 Q349 K379 Q380 Q507 E510 Q511 K518 R546 K635 T636 R637 T662 G663 T667 N668 T697 S698 N720 C829 H830 F853 K858 I875 V886 K888
Binding residue
(residue number reindexed from 1)		N59 Q60 I61 S86 G87 T108 Q110 K140 Q141 Q260 E263 Q264 K271 R299 K388 T389 R390 T415 G416 T420 N421 T450 S451 N473 C580 H581 F604 K609 I626 V637 K639
Binding affinityPDBbind-CN: Kd=38.5nM
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5f9f, PDBe:5f9f, PDBj:5f9f
PDBsum5f9f
PubMed26733676
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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