Structure of PDB 5f8g Chain A Binding Site BS01

Receptor Information
>5f8g Chain A (length=462) Species: 39054 (Enterovirus A71) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEIQWVKPNKETGRLNINGPTRTKLEPSVFHDVFEGNKEPAVLHSKDPRL
EVDFEQALFSKYVGNTLYEPDEYIKEAALHYANQLKQLDIDTSQMSMEEA
CYGTENLEAIDLHTSAGYPYSALGIKKRDILDSTTRDVSKMKFYMDKYGL
DLPYSTYVKDELRSIDKIKKGKSRLIEASSLNDSVYLRMTFGHLYETFHA
NPGTVTGSAVGCNPDTFWSKLPILLPGSLFAFDYSGYDASLSPVWFRALE
LVLREIGYSEEAVSLVEGINHTHHVYRNKTYCVLGGMPSGCSGTSIFNSM
INNIIIRALLIKTFKGIDLDELNMVAYGDDVLASYPFPIDCLELARTGKE
YGLTMTPADKSPCFNEVNWDNATFLKRGFLPDEQFPFLIHPTMPMKEIHE
SIRWTKDARNTQDHVRSLCLLAWHNGKQEYEKFVSAIRSVPVGKALAIPN
YENLRRNWLELF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5f8g Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation
Resolution2.78 Å
Binding residue
(original residue number in PDB)		P20 K24 E108 T114 S115 S121 K127 Y157 K159 I176 A178 R188 H199 G211 C212 N213 S289 G290 C291 S292 R416 L420
Binding residue
(residue number reindexed from 1)		P20 K24 E108 T114 S115 S121 K127 Y157 K159 I176 A178 R188 H199 G211 C212 N213 S289 G290 C291 S292 R416 L420
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5f8g, PDBe:5f8g, PDBj:5f8g
PDBsum5f8g
PubMed27339134
UniProtE5RPG3

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