Structure of PDB 5f74 Chain A Binding Site BS01

Receptor Information
>5f74 Chain A (length=229) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYK
NVVGARRSSWRVISSIEQKTNEKKQQMGKEYREKIEAELQDICNDVLELL
DKYLILNATQAESKVFYLKMKGDYFRYLSEVASGENKQTTVSNSQQAYQE
AFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIA
ELDTLNEESYKDSTLIMQLLRDNLTLWTS
Ligand information
>5f74 Chain B (length=20) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
RDKIRLNNAIWRAWYIQYVQ
Receptor-Ligand Complex Structure
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PDB5f74 Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		R58 R62 S66 Y181 E182 T217 L218 Q221 D225 N226
Binding residue
(residue number reindexed from 1)		R57 R61 S65 Y178 E179 T214 L215 Q218 D222 N223
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004860 protein kinase inhibitor activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding
GO:0050815 phosphoserine residue binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0006605 protein targeting
GO:0043085 positive regulation of catalytic activity
GO:0045184 establishment of protein localization
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway
GO:0051220 cytoplasmic sequestering of protein
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0042470 melanosome
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5f74, PDBe:5f74, PDBj:5f74
PDBsum5f74
PubMed26984404
UniProtQ9CQV8|1433B_MOUSE 14-3-3 protein beta/alpha (Gene Name=Ywhab)

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