Structure of PDB 5f5k Chain A Binding Site BS01

Receptor Information

>5f5k Chain A (length=178) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHA
LMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKF
SGPWFGGLSGVVFALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWF
DLMSMANGAHIAGLAVGLAMAFVDSLNA

Ligand information

>5f5k Chain B (length=4) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

VRMA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5f5k Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	M120 H150 W196 F197 G198 G199 S201 S248 M249 A250
Binding residue (residue number reindexed from 1)	M28 H58 W104 F105 G106 G107 S109 S154 M155 A156

Enzymatic activity

Enzyme Commision number

3.4.21.105: rhomboid protease.

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:5f5k, PDBe:5f5k, PDBj:5f5k
PDBsum	5f5k
PubMed	26805573
UniProt	P09391\|GLPG_ECOLI Rhomboid protease GlpG (Gene Name=glpG)

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