Structure of PDB 5f59 Chain A Binding Site BS01

Receptor Information
>5f59 Chain A (length=148) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIR
NEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCV
AEVVTFERGHKIIISSSRRIQKGEELCYDYKFDKIPCHCGAVNCRKWM
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5f59 Chain A Residue 5001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5f59 Structural basis for activity regulation of MLL family methyltransferases.
Resolution2.801 Å
Binding residue
(original residue number in PDB)		C4851 C4899 C4901 C4906
Binding residue
(residue number reindexed from 1)		C95 C137 C139 C144
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Y4800 I4876
Catalytic site (residue number reindexed from 1) Y44 I120
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB RCSB:5f59, PDBe:5f59, PDBj:5f59
PDBsum5f59
PubMed26886794
UniProtQ8NEZ4|KMT2C_HUMAN Histone-lysine N-methyltransferase 2C (Gene Name=KMT2C)

[Back to BioLiP]