Structure of PDB 5f2t Chain A Binding Site BS01

Receptor Information

>5f2t Chain A (length=247) Species: 246196 (Mycolicibacterium smegmatis MC2 155)

GGPEQLRRNLARVVGKPPADVPDDLIRASLASYARYWREAFRLPAMDHGR
LGEQLDVIDIDHLWSALDAGRGAVLALPHSGNWDMAGVWLVQNYGPFTTV
AERLKPESLYRRFVEYRESLGFEVLPLTGGERPPFEVLAERLTDNRPICL
MAERDLTRSGVQVDFFGEATRMPAGPAKLAIETGAALFPVHCWFEGDGWG
MRVYPELDTSSGDVTAITQALADRFAANIATYPADWHMLQPQWIADL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5f2t Chain A Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5f2t Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
• Resolution: 2.06 Å
• Binding residue (original residue number in PDB): D255 S257
• Binding residue (residue number reindexed from 1): D208 S210
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.3.1.265: phosphatidylinositol dimannoside acyltransferase.

Gene Ontology

Molecular Function

• GO:0016740 transferase activity
• GO:0016746 acyltransferase activity

Biological Process

• GO:0008654 phospholipid biosynthetic process
• GO:0009247 glycolipid biosynthetic process
• GO:0046488 phosphatidylinositol metabolic process

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5f2t, PDBe:5f2t, PDBj:5f2t
• PDBsum: 5f2t
• PubMed: 26965057
• UniProt: A0QWG5|ACYLT_MYCS2 Phosphatidylinositol mannoside acyltransferase (Gene Name=patA)