Structure of PDB 5ewg Chain A Binding Site BS01

Receptor Information
>5ewg Chain A (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSGTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ewg Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase eta.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		Y39 W42 S62 R93 K311 R313 P316 K317 T318 I319 G320 C321 S322 K323 N324 P326 R351
Binding residue
(residue number reindexed from 1)		Y42 W45 S65 R96 K306 R308 P311 K312 T313 I314 G315 C316 S317 K318 N319 P321 R346
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5ewg, PDBe:5ewg, PDBj:5ewg
PDBsum5ewg
PubMed26740629
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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