Structure of PDB 5ewf Chain A Binding Site BS01

Receptor Information
>5ewf Chain A (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAI
ERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRK
IRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRG
IEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTK
DRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIK
NCNTSTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB5ewf Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase eta.
Resolution1.782 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 R61 S62 K86 K311 R313 P316 K317 T318 I319 G320 C321 S322 K323 N324 P326 G327 R351
Binding residue
(residue number reindexed from 1)		Q41 Y42 W45 R64 S65 K89 K307 R309 P312 K313 T314 I315 G316 C317 S318 K319 N320 P322 G323 R347
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5ewf, PDBe:5ewf, PDBj:5ewf
PDBsum5ewf
PubMed26740629
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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