Structure of PDB 5eu8 Chain A Binding Site BS01

Receptor Information

>5eu8 Chain A (length=300) Species: 11135 (Feline infectious peritonitis virus)

SSGLRKMAQPSGVVEPCIVRVAYGNNVLNGLWLGDEVICPRHVIASDTSR
VINYENELSSVRLHNFSIAKNNAFLGVVSAKYKGVNLVLKVNQVNPNTPE
HKFKSVRPGESFNILACYEGCPGSVYGVNMRSQGTIKGSFIAGTCGSVGY
VLENGTLYFVYMHHLELGNGSHVGSNLEGEMYGGYEDQPSMQLEGTNVMS
SDNVVAFLYAALINGERWFVTNTSMTLESYNAWAKTNSFTEIVSTDAFNM
LAAKTGYSVEKLLECIVRLNKGFGGRTILSYGSLCDEFTPTEVIRQMYGV

Ligand information

>5eu8 Chain B (length=5) Species: 32630 (synthetic construct)

gAVLa

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5eu8 Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors
• Resolution: 2.447 Å
• Binding residue (original residue number in PDB): H41 C144 H163 L164 E165 Q187 P188 S189 M190
• Binding residue (residue number reindexed from 1): H42 C145 H164 L165 E166 Q188 P189 S190 M191

Enzymatic activity

• Catalytic site (original residue number in PDB): H41 G142 C144
• Catalytic site (residue number reindexed from 1): H42 G143 C145
• Enzyme Commision number: 2.1.1.57: methyltransferase cap1.
  2.7.7.48: RNA-directed RNA polymerase.
  2.7.7.50: mRNA guanylyltransferase.
  3.1.13.-
  3.4.19.12: ubiquitinyl hydrolase 1.
  3.4.22.-
  3.6.4.12: DNA helicase.
  3.6.4.13: RNA helicase.
  4.6.1.-

Gene Ontology

Molecular Function

• GO:0008233 peptidase activity

Biological Process

• GO:0019082 viral protein processing

External links

• PDB: RCSB:5eu8, PDBe:5eu8, PDBj:5eu8
• PDBsum: 5eu8
• PubMed: 26656689
• UniProt: Q98VG9|R1AB_FIPV Replicase polyprotein 1ab (Gene Name=rep)