Structure of PDB 5epi Chain A Binding Site BS01

Receptor Information
>5epi Chain A (length=703) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVIS
DMNFLDEEGKAYTARPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKYLAD
LFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLSNE
SSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDIDFKLGQTISRLRD
ISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKLTWEDLR
PIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLAKECLEKY
STLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNELQKTNYAK
WATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTEMNLLSTL
TSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMKYVLFHT
SLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHLRGDTDV
VTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLYCRVNGTN
KIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKGDRVNSPK
TFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAESRRLLL
LIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNEWLGFEKEG
SKV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5epi Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		K330 T366 G367 G369 L370 T371 Y372 Q504 H506 V513 T515 R558 V559 N560 G561
Binding residue
(residue number reindexed from 1)		K317 T353 G354 G356 L357 T358 Y359 Q491 H493 V500 T502 R545 V546 N547 G548
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5epi, PDBe:5epi, PDBj:5epi
PDBsum5epi
PubMed26711008
UniProtQ5V8Z9

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