Structure of PDB 5en1 Chain A Binding Site BS01

Receptor Information
>5en1 Chain A (length=184) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRS
RGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTV
KKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFD
DHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5en1 Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1
Resolution2.58 Å
Binding residue
(original residue number in PDB)		K22 F24 D49 V51 M53 F64 F66 A96 V97 R99 H108
Binding residue
(residue number reindexed from 1)		K11 F13 D38 V40 M42 F53 F55 A85 V86 R88 H97
Binding affinityPDBbind-CN: Kd=276.2nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:5en1, PDBe:5en1, PDBj:5en1
PDBsum5en1
PubMed
UniProtP22626|ROA2_HUMAN Heterogeneous nuclear ribonucleoproteins A2/B1 (Gene Name=HNRNPA2B1)

[Back to BioLiP]