Structure of PDB 5ejv Chain A Binding Site BS01

Receptor Information

>5ejv Chain A (length=245) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKS
MWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVL
VRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHF
SEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSI
LAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS

Ligand information

>5ejv Chain C (length=11) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

EFPYLLSLLGE

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5ejv Discovery of biaryls as ROR gamma inverse agonists by using structure-based design.
Resolution	2.58 Å
Binding residue (original residue number in PDB)	K336 Q346 K354 P500 E504
Binding residue (residue number reindexed from 1)	K74 Q84 K92 P238 E242

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Molecular Function

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Cellular Component

External links

PDB	RCSB:5ejv, PDBe:5ejv, PDBj:5ejv
PDBsum	5ejv
PubMed	27080181
UniProt	P51449\|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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