Structure of PDB 5ean Chain A Binding Site BS01

Receptor Information
>5ean Chain A (length=1051) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGHMEPLDELDLLLLEAVPRVELLRKKADALFPETVLSRGVDNRYLVLAV
ETSQNERGAEEKRLHVTASQDREHEVLCILRNGWSSVPVEPGDIVHLEGD
CTSEPWIIDDDFGYFILYPDMMISGTSVASSIRCLRRAVLSETFRGSDPA
TRQMLIGTILHEVFQKAISESFAPERLQELALQTLREVRHLKEMYRLNLS
QDEILCEVEEYLPSFSKWAEDFMRKGPSSEFPQMQLSLPSDGRSSPCNIE
VVKSLDIEESIWSPRFGLKGKIDVTVGVKIHRDCKMKYKVMPLELKTGKE
SNSIEHRSQVVLYTLLSQERREDPEAGWLLYLKTGQMYPVPANHLDKREL
LKLRNWLAASLLHRVSRAAPGEEARLSALPQIIEEEKTCKYCSQIGNCAL
YSRAVEEQGDDASIPEAMLSKIQEETRHLQLAHLKYFSLWCLMLTLESQS
KDNRKTHQSIWLTPASELEESGNCVGNLVRTEPVSRVCDGQYLHNFQRKN
GPMPATNLMAGDRIILSGEERKLFALSKGYVKKMNKAAVTCLLDRNLSTL
PATTVFRLDREERHGDISTPLGNLSKLMESTDPSKRLRELIIDFREPQFI
AYLSSVLPHDAKDTVANILKGLNKPQRQAMKRVLLSKDYTLIVGMPGTGK
TTTICALVRILSACGFSVLLTSYTHSAVDNILLKLAKFKVGFLRLGQSHK
VHPDIQKFTEEEICRSRSIASLAHLEELYNSHPIVATTCMGINHPIFSRK
TFDFCIVDEASQISQPVCLGPLFFSRRFVLVGDHQQLPPLVVNREARALG
MSESLFKRLERNESAVVQLTVQYRMNRKIMSLSNKLTYAGKLECGSDRVA
NAVLALPNLKDARLSLQLYADYSDSPWLAGVLEPDNPVCFLNTDKVPAPE
QVENGGVSNVTEARLIVFLTSTFIKAGCSPSDIGVIAPYRQQLRIISDLL
ARSSVGMVEVNTVDKYQGRDKSLILVSFVRSNEDGTLGELLKDWRRLNVA
LTRAKHKLILLGSVSSLKRFPPLGTLFDHLNAEQLILDLPSREHESLSHI
L
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5ean Dna2 nuclease-helicase structure, mechanism and regulation by Rpa.
Resolution2.36 Å
Binding residue
(original residue number in PDB)		S127 T129 M157 T161 H164 K274 G275 K276 D278 K301 T302 Y318 S398 R518 R568 Y678 T679 H680 T743 M745 L795 G910 R945 T967 D969 K970 G993 E994 L995 R1001
Binding residue
(residue number reindexed from 1)		S124 T126 M154 T158 H161 K269 G270 K271 D273 K296 T297 Y313 S393 R513 R563 Y673 T674 H675 T738 M740 L790 G905 R940 T962 D964 K965 G988 E989 L990 R996
Enzymatic activity
Enzyme Commision number 3.1.-.-
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base
GO:0017108 5'-flap endonuclease activity
GO:0017116 single-stranded DNA helicase activity
GO:0043139 5'-3' DNA helicase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000076 DNA replication checkpoint signaling
GO:0000723 telomere maintenance
GO:0000729 DNA double-strand break processing
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006264 mitochondrial DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0032508 DNA duplex unwinding
GO:0033567 DNA replication, Okazaki fragment processing
GO:0043137 DNA replication, removal of RNA primer
GO:0043504 mitochondrial DNA repair
GO:0045740 positive regulation of DNA replication
GO:0090304 nucleic acid metabolic process
GO:1902990 mitotic telomere maintenance via semi-conservative replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005760 gamma DNA polymerase complex
GO:0042645 mitochondrial nucleoid

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5ean, PDBe:5ean, PDBj:5ean
PDBsum5ean
PubMed26491943
UniProtQ6ZQJ5|DNA2_MOUSE DNA replication ATP-dependent helicase/nuclease DNA2 (Gene Name=Dna2)

[Back to BioLiP]