Structure of PDB 5e8i Chain A Binding Site BS01

Receptor Information
>5e8i Chain A (length=93) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGERKSKP
NMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQP
Ligand information
Receptor-Ligand Complex Structure
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PDB5e8i Structural Basis for Dimerization and DNA Binding of Transcription Factor FLI1.
Resolution3.45 Å
Binding residue
(original residue number in PDB)		Y332 R337 R340 Y341 Y343 K350 R355 Y356
Binding residue
(residue number reindexed from 1)		Y54 R59 R62 Y63 Y65 K72 R77 Y78
Binding affinityPDBbind-CN: Kd=16nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:5e8i, PDBe:5e8i, PDBj:5e8i
PDBsum5e8i
PubMed26618620
UniProtQ01543|FLI1_HUMAN Friend leukemia integration 1 transcription factor (Gene Name=FLI1)

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