Structure of PDB 5e5o Chain A Binding Site BS01

Receptor Information
>5e5o Chain A (length=294) Species: 771870 (Sordaria macrospora k-hell) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLNPWAVVGFIDAEGSFMVRVRKNSKYKTGWLVVAIFSVTVDKKDLFLLE
SLKTFFGGLGSIKKSGNSTFSYRIESSEQLTKIILPFFDKYSLITEKLGD
YLLFKKVLELMGTKEHLTQRGLEKIVSLKASINKGLSEELQAAFPQCVPT
PRPEINNKNIPDPFWLAGFVSGDGSFKSILKKSESIKVGFQSILVFQITQ
HARDVKLMESLISYLGCGFIEKDSRGPWLYYTVTNFSDIQGKIIPFFHQY
KIIGSKYGDYMDWCKIALIMQNKNHLTPEGLNEIRALKGGMNKG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5e5o The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease.
Resolution2.36 Å
Binding residue
(original residue number in PDB)		E20 M24 R26 R28 T46 V47 D48 R79 N139 S191 I192 K193 Q197 F225 R231 T240 N241 F242 H281 L282
Binding residue
(residue number reindexed from 1)		E14 M18 R20 R22 T40 V41 D42 R73 N133 S185 I186 K187 Q191 F219 R225 T234 N235 F236 H275 L276
Binding affinityPDBbind-CN: Kd~150nM
Enzymatic activity
Catalytic site (original residue number in PDB) G178 D179
Catalytic site (residue number reindexed from 1) G172 D173
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:5e5o, PDBe:5e5o, PDBj:5e5o
PDBsum5e5o
PubMed26705195
UniProtF7WD42

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