Structure of PDB 5e3h Chain A Binding Site BS01

Receptor Information
>5e3h Chain A (length=642) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQK
GKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVEN
NDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNY
LDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIA
TVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRIC
KDLEFGTQKYEQWIVTVQKACMVFDKDEESRICKALFLYTSHLRKYNDAL
IISEHARMKDALDYLKDFFSNVRAEIEQDLTQRFEEKLQELESVSRDPSN
ENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFL
KPGILTGRGTGMTLPAQKCILDAFKDHNILIATSVADEGIDIAQCNLVIL
YEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDS
ILRLQTWDEAVFREKILHIQTHEKFIRDSQEVPDKENKKLLCRKCKALAC
YTADVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARCS
HDWGIHVKYKTFEIPVIKIESFTLYSKWKDFHFEKIPFDPAE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5e3h Structural basis of RNA recognition and activation by innate immune receptor RIG-I.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		K379 Q380 H381 Q507 Q511 N720 H830 F853 I875 V886 K888 W908
Binding residue
(residue number reindexed from 1)		K139 Q140 H141 Q258 Q262 N456 H562 F585 I605 V616 K618 W628
Binding affinityPDBbind-CN: Kd=0.02nM
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5e3h, PDBe:5e3h, PDBj:5e3h
PDBsum5e3h
PubMed21947008
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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