Structure of PDB 5e3c Chain A Binding Site BS01

Receptor Information
>5e3c Chain A (length=724) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTQYILPNDIGVSSLDSREAFRLLSPTERLYAYHLSRAAWYGGLAVLLQT
SPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSN
MGNYKSFGDTKFVPNLPKEKLERVILGSEAAQQHPEEVRGLWQTCGELMF
SLEPRLRHLGLGKEGITTYFSGNCTMEDAKLAQDFLDSQNLSAYNTRLFK
EVDGCGKPYYEVRLASVLGSEPSLDSEVTSKLKSYEFRGSPFQVTRGDYA
PILQKVVEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFWIQ
DKGPIVESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAEQ
LLKELPWPPTFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTE
GFKNVSLGNVLAVAYATQREKLTFLEEDDKDLYILWKGPSFDVQVGLHAL
LGHGSGKLFVQDEKGAFNFDQETVINPETGEQIQSWYRCGETWDSKFSTI
ASSYEECRAESVGLYLSLHPQVLEIFGFEGADAEDVIYVNWLNMVRAGLL
ALEFYTPEAFNWRQAHMQARFVILRVLLEAGEGLVTITPTTGSDGRPDAR
VRLDRSKIRSVGKPALERFLRRLQVLKSTGDVAGGRALYEGYATVTDAPP
ESFLTLRDTVLLRKESRKLIVQPNTRLEGSDVQLLEYEASAAGLIRSFSE
RFPEDGPELEEILTQLATADARFW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5e3c Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition.
Resolution2.765 Å
Binding residue
(original residue number in PDB)		E316 Y318 I386 P387 A388 G389 I390 N391 N394 F443 V447 H450 E508 E512 H568 R669 K670
Binding residue
(residue number reindexed from 1)		E314 Y316 I384 P385 A386 G387 I388 N389 N392 F441 V445 H448 E506 E510 H566 R667 K668
Enzymatic activity
Enzyme Commision number 3.4.14.4: dipeptidyl-peptidase III.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008235 metalloexopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0030163 protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5e3c, PDBe:5e3c, PDBj:5e3c
PDBsum5e3c
PubMed27025154
UniProtQ9NY33|DPP3_HUMAN Dipeptidyl peptidase 3 (Gene Name=DPP3)

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