Structure of PDB 5e33 Chain A Binding Site BS01

Receptor Information
>5e33 Chain A (length=725) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADTQYILPNDIGVSSLDSREAFRLLSPTERLYAYHLSRAAWYGGLAVLLQ
TSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYS
NMGNYKSFGDTKFVPNLPKEKLERVILGSEAAQQHPEEVRGLWQTCGELM
FSLEPRLRHLGLGKEGITTYFSGNCTMEDAKLAQDFLDSQNLSAYNTRLF
KEVDGCGKPYYEVRLASVLGSEPSLDSEVTSKLKSYEFRGSPFQVTRGDY
APILQKVVEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFWI
QDKGPIVESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAE
QLLKELPWPPTFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQT
EGFKNVSLGNVLAVAYATQREKLTFLEEDDKDLYILWKGPSFDVQVGLHA
LLGHGSGKLFVQDEKGAFNFDQETVINPETGEQIQSWYRCGETWDSKFST
IASSYEECRAESVGLYLSLHPQVLEIFGFEGADAEDVIYVNWLNMVRAGL
LALEFYTPEAFNWRQAHMQARFVILRVLLEAGEGLVTITPTTGSDGRPDA
RVRLDRSKIRSVGKPALERFLRRLQVLKSTGDVAGGRALYEGYATVTDAP
PESFLTLRDTVLLRKESRKLIVQPNTRLEGSDVQLLEYEASAAGLIRSFS
ERFPEDGPELEEILTQLATADARFW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5e33 Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition.
Resolution1.837 Å
Binding residue
(original residue number in PDB)		E316 Y318 P387 A388 G389 I390 N391 N394 R399 H455 H568
Binding residue
(residue number reindexed from 1)		E315 Y317 P386 A387 G388 I389 N390 N393 R398 H454 H567
Enzymatic activity
Enzyme Commision number 3.4.14.4: dipeptidyl-peptidase III.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008235 metalloexopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0030163 protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5e33, PDBe:5e33, PDBj:5e33
PDBsum5e33
PubMed27025154
UniProtQ9NY33|DPP3_HUMAN Dipeptidyl peptidase 3 (Gene Name=DPP3)

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