Structure of PDB 5dv8 Chain A Binding Site BS01

Receptor Information

>5dv8 Chain A (length=269) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSL
MMGEDKIKFKHITPLSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVN
LDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRK
PFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIED
IQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKK
TETDMSLHPLLQEIYKDLY

Ligand information

>5dv8 Chain B (length=10) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

HKILHRLLQE

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5dv8 Human PPARgamma ligand binding dmain complexed with SB1451 in a covalent bonded form
Resolution	2.75 Å
Binding residue (original residue number in PDB)	K301 L311 Q314 V315 L318 K319 L468 E471
Binding residue (residue number reindexed from 1)	K93 L103 Q106 V107 L110 K111 L260 E263

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:5dv8, PDBe:5dv8, PDBj:5dv8
PDBsum	5dv8
PubMed
UniProt	P37231\|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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