Structure of PDB 5dnn Chain A Binding Site BS01

Receptor Information
>5dnn Chain A (length=97) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSS
AVMALQEASEAYLVALFEDTNLCAIHAKRVTIMPKDIQLARRIRGER
Ligand information
>5dnn Chain I (length=145) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcaatatccacctgcagatactaccaaaagtgtatttggaaactgctcc
atcaaaaggcatgttcagctgaatcagctgaacatgccttttgatggagc
agtttccaaatacacttttggtagtatctgcaggtggatattgat
Receptor-Ligand Complex Structure
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PDB5dnn Allosteric cross-talk in chromatin can mediate drug-drug synergy
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R40 Y41 R42 P43 T45 R63 R72 R83 F84 S86 R116 V117 T118
Binding residue
(residue number reindexed from 1)		R3 Y4 R5 P6 T8 R26 R35 R46 F47 S49 R79 V80 T81
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:5dnn, PDBe:5dnn, PDBj:5dnn
PDBsum5dnn
PubMed28358030
UniProtP84233|H32_XENLA Histone H3.2

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