Structure of PDB 5dmm Chain A Binding Site BS01

Receptor Information
>5dmm Chain A (length=288) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NPLRALLDKQDILLLDGAMATELEARGCNLADSLWSAKVLVENPELIREV
HLDYYRAGAQCAITASYQATPAGFAARGLDEAQSKALIGKSVELARKARE
AYLAENPQAGTLLVAGSVGPYGAYLADGSEYRGDYHCSVEAFQAFHRPRV
EALLDAGADLLACETLPNFSEIEALAELLTAYPRARAWFSFTLRDSEHLS
DGTPLRDVVALLAGYPQVVALGINCIALENTTAALQHLHGLTVLPLVVYP
NSGQLADYLPQWQAAGARLIGGCCRTTPADIAALKARS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5dmm Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5dmm Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli.
Resolution1.779 Å
Binding residue
(original residue number in PDB)		C229 C295
Binding residue
(residue number reindexed from 1)		C225 C273
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.10: homocysteine S-methyltransferase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity
GO:0046872 metal ion binding
GO:0061627 S-methylmethionine-homocysteine S-methyltransferase activity
Biological Process
GO:0006974 DNA damage response
GO:0009086 methionine biosynthetic process
GO:0032259 methylation
GO:0033477 S-methylmethionine metabolic process
GO:0033528 S-methylmethionine cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:5dmm, PDBe:5dmm, PDBj:5dmm
PDBsum5dmm
PubMed26564203
UniProtQ47690|MMUM_ECOLI Homocysteine S-methyltransferase (Gene Name=mmuM)

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