Structure of PDB 5dll Chain A Binding Site BS01

Receptor Information
>5dll Chain A (length=854) Species: 177416 (Francisella tularensis subsp. tularensis SCHU S4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KIKYLKDYKPSNYLIDETHLIFELDESKTRVTANLYIVANRENRENNTLV
LDGVELKLLSIKLNNKHLSPAEFAVNENQLIINNVPEKFVLQTVVEINPS
ANTSLEGLYKSGDVFSTQCEATGFRKITYYLDRPDVMAAFTVKIIADKKK
YPIILSNGDKIDSGDISDNQHFAVWKDPFKKPCYLFALVAGDLASIKDTY
ITKSQRKVSLEIYAFKQDIDKCHYAMQAVKDSMKWDEDRFGLEYDLDTFM
IVAVPDFNAGAMENKGLNIFNTKYIMASNKTATDKDFELVQSVVGHEYFH
NWTGDRVTCRDWFQLSLKEGLTVFRDQEFTSDLNSRDVKRIDDVRIIRSA
QFAEDASPMSHPIRPESYIEMNNFYTVTVYNKGAEIIRMIHTLLGEEGFQ
KGMKLYFERHDGQAVTCDDFVNAMADANNRDFSLFKRWYAQSGTPNIKVS
ENYDASSQTYSLTLEQTTLPTADQKEKQALHIPVKMGLINPEGKNIAEQV
IELKEQKQTYTFENIAAKPVASLFRDFSAPVKVEHKRSEKDLLHIVKYDN
NAFNRWDSLQQIATNIILNNADLNDEFLNAFKSILHDKDLDKALISNALL
IPIESTIAEAMRVIMVDDIVLSRKNVVNQLADKLKDDWLAVYQQCNDNKP
YSLSAEQIAKRKLKGVCLSYLMNASDQKVGTDLAQQLFDNADNMTDQQTA
FTELLKSNDKQVRDNAINEFYNRWRHEDLVVNKWLLSQAQISHESALDIV
KGLVNHPAYNPKNPNKVYSLIGGFGANFLQYHCKDGLGYAFMADTVLALD
KFNHQVAARMARNLMSWKRYDSDRQAMMKNALEKIKASNPSKNVFEIVSK
SLES
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5dll Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5dll Aminopeptidase N (pepN) from Francisella tularensis subsp. tularensis SCHU S4
Resolution2.51 Å
Binding residue
(original residue number in PDB)		H306 H310 E329
Binding residue
(residue number reindexed from 1)		H296 H300 E319
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) E273 H306 E307 H310 E329 N382 Y390
Catalytic site (residue number reindexed from 1) E263 H296 E297 H300 E319 N372 Y380
Enzyme Commision number 3.4.11.2: membrane alanyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5dll, PDBe:5dll, PDBj:5dll
PDBsum5dll
PubMed
UniProtQ5NE65

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