Structure of PDB 5dlg Chain A Binding Site BS01

Receptor Information
>5dlg Chain A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRA
AIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPI
RKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMC
RGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERL
TKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTV
IKNCNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB5dlg Lesion Orientation ofO4-Alkylthymidine Influences Replication by Human DNA Polymeraseeta.
Resolution2.351 Å
Binding residue
(original residue number in PDB)		R61 E116 S257 G259 G260 K261 L262 R377 L381 R382 R383
Binding residue
(residue number reindexed from 1)		R64 E119 S255 G257 G258 K259 L260 R375 L379 R380 R381
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5dlg, PDBe:5dlg, PDBj:5dlg
PDBsum5dlg
PubMed27574558
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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