Structure of PDB 5dfh Chain A Binding Site BS01

Receptor Information
>5dfh Chain A (length=275) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDIL
CLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKV
SYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAF
RKFLKGLARKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGEL
LQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLP
ALCDSKIRSKALGSDHCPITLYLAL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5dfh Capturing snapshots of APE1 processing DNA damage.
Resolution1.949 Å
Binding residue
(original residue number in PDB)		E96 Y171 N174 R177 D210 N212 N222 N226 A230 F266 M271 K276 V278 W280 L282 H309
Binding residue
(residue number reindexed from 1)		E54 Y129 N132 R135 D167 N169 N179 N183 A187 F223 M228 K233 V235 W237 L239 H266
Enzymatic activity
Catalytic site (original residue number in PDB) N68 D70 E96 Y171 D210 N212 D283 D308 H309
Catalytic site (residue number reindexed from 1) N26 D28 E54 Y129 D167 N169 D240 D265 H266
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
3.1.21.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5dfh, PDBe:5dfh, PDBj:5dfh
PDBsum5dfh
PubMed26458045
UniProtP27695|APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (Gene Name=APEX1)

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