Structure of PDB 5df6 Chain A Binding Site BS01
Receptor Information
>5df6 Chain A (length=212) Species:
9606
(Homo sapiens) [
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RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTH
IKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN
CADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRT
GDDKGESKSKVTHVMIRCQKYDVGGGERFDSLTDLVEHYKKNPMVETLGT
VLQLKQPLNTTR
Ligand information
>5df6 Chain B (length=6) Species:
9606
(Homo sapiens) [
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TYTEVD
Receptor-Ligand Complex Structure
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PDB
5df6
Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.
Resolution
1.78 Å
Binding residue
(original residue number in PDB)
R32 K35 S36 T42 T52 H53 Q87 L88 K89 E90 K91
Binding residue
(residue number reindexed from 1)
R29 K32 S33 T39 T49 H50 Q84 L85 K86 E87 K88
Enzymatic activity
Enzyme Commision number
3.1.3.48
: protein-tyrosine-phosphatase.
External links
PDB
RCSB:5df6
,
PDBe:5df6
,
PDBj:5df6
PDBsum
5df6
PubMed
26527736
UniProt
Q06124
|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)
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